I have two twitter accounts. With one of them, I follow upward of 700 people and use the account to share information and learn about the internet world. I don't check it everyday, and I certainly don't read every tweet.
On my other account, I follow my friends and other people who I actually want to keep in touch with and talk to on a regular basis, as well as organzations I care about or want to get constant updates from. I only have about 70 people that I follow from this account, and I read every single tweet as it comes to my phone.
One of my friends (@bigsamthompson) recommended a few people to follow because they have interesting updates, including @iamsh4wn and the musician @johncmayer. I followed these from my more personal account, since I wanted to actually get and enjoy their tweets.
While I do enjoy John Mayer's music, it's not my favorite. His music is not why I follow him. I follow him because his tweets are fun to read, and they make my day a little brighter/thoughtful/something. However, since he is a "famous musician," smaller bands piggyback off of his fame. I've had a few bands/singers/songwriters that I've never heard of start following me, and I'm not sure what to do about it. I've followed them back for now, and a couple of them have interesting things to say. However, they also mention their music a bit more than I'd like. Also, since I've followed a couple of them, even more have decided to add me. I'm not really sure how I feel about musicians on twitter trying to get more people interested in their work. I feel as though twitter should be a place to connect with your existing fanbase, or even people who don't really care about your music but think you're an interesting person.